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New Medicines

What’s approved, what’s still in trials, and how to read the headlines about new GLP-1 medicines.

A stack of plain sealed envelopes on a dark wooden desk lit by a brass desk lamp.New Medicines

FDA GLP-1 Telehealth Warning Letters: What They Said in 2026

Since September 2025 the FDA has sent waves of warning letters to telehealth companies selling compounded GLP-1s. Here is the timeline, the exact phrases regulators objected to, and what that teaches you as a shopper.

7 min readOct 27, 2026
Research papers and charts beside a tablet, representing clinical-trial evaluation.New Medicines

CagriSema Explained: Semaglutide Plus Cagrilintide

CagriSema pairs semaglutide with the amylin analogue cagrilintide. See what its trials found, how it fared against tirzepatide and where FDA review stands.

3 min readOct 11, 2026
Laboratory glassware lined up on a bench, representing the stages of clinical research.New Medicines

Clinical Trial Phases Explained for Weight-Loss Drugs

Phase 1, 2 and 3 trials answer different questions about safety and effectiveness. Learn to read weight-loss drug headlines without overreading early results.

4 min readOct 11, 2026
A pill organizer and glass of water, representing a new oral medicine.New Medicines

Foundayo: What to Know About the New Oral Weight-Loss Medicine

Foundayo (orforglipron) is a daily GLP-1 pill approved in the US in April 2026 for weight management. What the label says, trial results and questions to ask.

4 min readOct 11, 2026
A microscope beside a notebook, representing how medicines are designed.New Medicines

GIP and GLP-1: What GIP Is and Why Tirzepatide Targets Both

What is GIP and how is it different from GLP-1? See why tirzepatide is a GIP/GLP-1 agonist, what the SURMOUNT-5 trial showed and which brand treats what.

4 min readOct 11, 2026
A person reviewing medication information on a tablet beside a notebook.New Medicines

GLP-1 Pills vs Injections: Convenience, Absorption and Evidence

GLP-1 pills and injections differ in routine, absorption, dose and approved uses. Compare US oral and weekly options and the questions worth asking first.

3 min readOct 11, 2026
A pill dish next to a pen case, representing oral and injectable options.New Medicines

Oral Wegovy vs Wegovy Injection: What Is Different?

The Wegovy pill and Wegovy injection both contain semaglutide, but dosing, routines, trials and approved uses differ. A clear US comparison and what to ask.

4 min readOct 11, 2026
Two lab flasks side by side, representing a comparison of medicines.New Medicines

Retatrutide vs Tirzepatide: What Can We Compare Yet?

Retatrutide is investigational; tirzepatide is approved. See what each trial found, why the numbers can't be ranked yet and which head-to-head trial to watch.

4 min readOct 11, 2026
Two medicine pen cases side by side, representing older and newer options.New Medicines

Semaglutide vs Liraglutide: Older and Newer GLP-1 Options

Semaglutide and liraglutide are both GLP-1 medicines but differ in dosing, brands, labels and results. See what the STEP 8 head-to-head trial found.

3 min readOct 11, 2026
A clinician's desk, representing questions about higher doses.New Medicines

Wegovy 7.2mg (Wegovy HD): What the High Dose Means

Wegovy 7.2mg (Wegovy HD) is the high-dose semaglutide pen approved in the US in March 2026. What the label says, trial results and side effects to know.

5 min readOct 11, 2026
Three vials in a lab rack, representing a triple-agonist medicine design.New Medicines

What Is a Triple Agonist? Understanding Retatrutide’s Drug Design

Retatrutide is built to act on GIP, GLP-1 and glucagon receptors. Learn what “triple agonist” means and why a clever design isn't the same as approval.

3 min readOct 11, 2026
A petri dish under a microscope light, representing hormone research.New Medicines

What Is Amylin? How It Differs From GLP-1 Signaling

Amylin is a hormone released with insulin after meals. Learn how it differs from GLP-1, why cagrilintide is studied with semaglutide and what's unproven.

3 min readOct 11, 2026
A scientist reviewing a laboratory study, representing the difference between research and approved medicine.New Medicines

Why You Cannot Treat an Investigational Drug Like an Approved Medicine

An investigational drug is still being tested for safety and effectiveness. Learn what FDA approval adds and why online “research” versions aren't safe swaps.

3 min readOct 11, 2026

Make your GLP-1 journey easier to track 💚

Keep your shots, weight, food, water and symptom notes together with GLPily, and meet Pily, the little coach who answers from your own logs.

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